Numerous scientific discoveries came by surprise and accident. They weren’t planned, expected and predicted. However, they served to be very useful to the world and the people who benefit most from it. One incident took place at the University of British Columbia where the researchers were experimenting on the deterioration of mice’s blood vessels.
Set up was, an enzyme known as Granzyme B was not found in one group of mice and the others were concocted with the enzyme. When the study concluded, one fascinating discovery that would make many so happy is that mice without Granzyme B resulted to have a very soft and wrinkle-free skin.
On the other hand, the group having the enzyme displayed signs of aging. Granzyme B is a “serine protease” enzyme. This kind can break other proteins in the body. It’s produced and released by the immune cells in the body termed NK and cytotoxic T-cells and has numerous functions in the body.
However, when the enzyme is secreted, they can also cause breakage of ECM (extracellular matrix). These are types of proteins and molecules that can fill in spaces amid cells. Furthermore, they stimulate the skin’s aging process.
Some tests were performed with the inclusion of some mice, such with normal levels of Granzyme B, to be displayed for limited junctures per week to a few minutes of UV light and one other group without the enzyme. After 20 weeks, the group where the mice don’t have the enzyme were seen to have wrinkle-free skin than the other with it.
Overall, the study revealed that Granzyme B levels are amplified by the sunlight which later minimizes the collagen and boosts wrinkles to begin in developing. If ever the skin cells are infested with a virus or when they create cancer mutations, they trigger the development more. On one hand, this can be instantaneously eliminated through a healthy immune system. This is because of the procedure known as “apoptosis” where the immune cells utilize the enzyme to create skin cells self-destruct.
Other treatments also exist in impeding Granzyme B, they can be either natural or synthetic. More than these treatments, what keeps Granzyme B a hit are the studies continually created to test whether the enzyme’s inhibitors can avert skin damaging – developing to photosensitivity – and scarring or not. Moreover, the aging blood vessels are also scrutinized if they can avert aneurysms.